Press "Enter" to skip to content

Apply These Secret WAYS TO Improve Pregnancy Loss And Chromosome Testing For Miscarriages

Although most couples are blissfully unaware of the statistics surrounding miscarriage, pregnancy loss is in fact quite common, with 10-25% of recognized pregnancies ending in miscarriage. In case you have suffered a pregnancy loss or are currently in the process of experiencing a miscarriage, you might be wondering what caused losing and worry about whether it will happen again. This short article aims to answer the following questions:

What causes miscarriage?
How common is pregnancy loss?
Which kind of genetic testing is available for miscarriage tissue?
How do chromosome testing help?
Causes of Miscarriage

There are many different reasons why miscarriage occurs, but the most typical cause for first trimester miscarriage is really a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also called “aneuploidy” – occur due to a mis-division of the chromosomes in the egg or sperm involved with a conception. Typically, humans have 46 chromosomes which come in 23 pairs (22 pairs numbered from 1 to 22 and the sex chromosomes, X and Y). For a baby to develop normally it is necessary that it have the right quantity of chromosome material; missing or extra material at the time of conception or in an embryo or fetus can cause a woman to either not get pregnant, miscarry, or have a baby with a chromosome syndrome such as Down syndrome.

Over 50% of all first trimester miscarriages are caused by chromosome abnormalities. This number could be closer to 75% or more for women aged 35 years and over who have experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep increase in women older than 35.

Pregnancy Loss – How Common could it be?

Miscarriage is a lot more common than a lot of people think. Up to one atlanta divorce attorneys four recognized pregnancies is lost in first trimester miscarriage. The chance of experiencing a miscarriage also increases as a mother ages.

Most women who experience a miscarriage continue to possess a healthy pregnancy rather than miscarry again. However, some women seem to be more prone to miscarriage than others. About five percent of fertile couples will experience several miscarriages.

Of note, the rate of miscarriage seems to be increasing. One reason for this may be awareness – more women know they are having a miscarriage because home pregnancy tests have improved early pregnancy detection rates over the past decade, whereas in past times the miscarriage would have appeared to be just an unusual period. Another reason could be that more women are conceiving at older ages.

Types of Genetic Testing Ideal for Miscarriages

Genetic testing actually refers to many types of testing that you can do on the DNA in a cell. For miscarriage tissue, also known as products of conception (POC), probably the most useful type of test to perform is a chromosome analysis. A chromosome analysis (also known as chromosome testing) can examine all 23 pairs of chromosomes for the presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are caused by aneuploidy, chromosome analysis on the miscarriage tissue could identify the reason for the pregnancy loss.

The most common approach to chromosome analysis is named karyotyping. Newer methods include advanced technologies such as microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, an activity called “cell culture”. For that reason requirement, tissue that’s passed at home is often unable to be tested with this method. About 20% or more of miscarriage samples neglect to grow and thus no results are available. Additionally, karyotyping is unable to tell the difference between cells from mom (maternal cells) and cells from the fetus. In case a normal female result is available, it may be the correct result for the fetus or it may be maternal cell contamination (MCC) where the result actually originates from testing the mother’s cells present in the pregnancy tissue rather than the fetal cells. MCC appears to occur in about 30% or even more of the samples tested by traditional karyotype. Results from karyotyping usually take a few weeks to months to come back from the laboratory.

Microarray testing is really a new kind of genetic testing done on miscarriage samples; the two most common types of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing is also able to test all 23 pairs of chromosomes for aneuploidy, but will not require cell culture. Therefore, you’re more likely to receive results and the outcomes are typically returned faster when microarray testing is used. Additionally, some laboratories are collecting an example of the mother’s blood concurrently the miscarriage tissue is delivered to enable immediate detection of maternal cell contamination (MCC).

infant loss Chromosome Testing – How do it help?

If a chromosome abnormality is identified, the kind of abnormality found could be assessed to help answer the question: “Will this happen to me again?”. More often than not, chromosome abnormalities in an embryo or fetus aren’t inherited and have a low chance to occur in future pregnancies. Sometimes, a specific chromosome finding in a miscarriage alerts your physician to do further studies to investigate the chance of an underlying genetic or chromosome problem in your family that predisposes you to have miscarriages.

Furthermore, if a chromosome abnormality is identified it could prevent the need for other, sometimes quite costly, studies your doctor might consider to investigate the reason for the miscarriage.

Lastly, knowing the explanation for a pregnancy loss can help a couple start the emotional healing process, moving past the question of “Why did this happen to me?”.

Chromosome testing can be especially important for patients with repeated miscarriages, as it could either give clues to an underlying chromosomal cause for the miscarriages or eliminate chromosome errors as the reason for the miscarriages and allow their doctor to pursue other styles of testing. For couples with multiple miscarriages determined to truly have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing might be able to help increase their chances of having an effective healthy pregnancy.

PhillipHumphers
PhillipHumphers

View all posts